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In this reference book for cancer care providers, Pre-Seed is listed as a water-soluble lubricant that does not decrease sperm motility.

In this medical text written by well-renowned experts, Dr. Craig Niederberger writes: "Virtually all lubricants impair sperm, including saliva. However, some couples need lubricants for intercourse. A recent survey of the effects of various lubricants on sperm motility and DNA quality suggested that Pre-Seed appears to have the least negative effect on sperm.”

The chapter on the initial consultation for male infertility states: "In 2008, in vitro studies suggest that a newer commercially available hydroxyethylcellulose-based lubricant, such as Pre-Seed, has minimal deleterious effects on mobility and sperm chromatin integrity.”

In this classic textbook for medical students, the authors write: "Lubricants may be toxic to sperm. A nontoxic lubricant, Preseed, has been developed for infertile couples."

In this laboratory guide, the authors state: "If a lubricant must be used then it must not show any toxicity to spermatozoa. Currently, the only suitable commercial product for this particular purpose is Pre’, an external use version of the Pre-Seed vaginal lubricant…"

In this book for nursing professionals, Pre-Seed is listed as a water-soluble lubricant that can reduce discomfort during intercourse.