Preseed.com Blog

Fertility & Sterility Sept 2009, has a Controversy section discussing which is better for ovulation induction Letrozole or CC (Clomid).  The moderator, Dr. Casper, states “Letrozole is at least as effective as clomiphene for inducing ovulation and achieving pregnancy in patients with poly-cystic ovarian syndrome. Potential advantages of letrozole include reduced multiple pregnancies, absence of anti-estrogenic adverse effects, and the subsequent need for less intensive monitoring”.  As the author notes Clomid wreaks havoc on cervical mucus, one of its “anti-estrogenic” side effects!  He goes on to state letrozole can be of benefit in patients for whom Clomid is not working.  This supports other studies which suggest that trying Clomid over and over is not beneficial for patients.  Finally, Dr. Casper suggest that Letrozole should perhaps be used more as a first ovulation induction therapy, versus Clomid. 

I would very much like to hear from you and your community if Letrozole has impacted your cervical mucus or arousal fluid for those of you who have used it.    

Finally, here is some exciting news from a PCOS gal that I received this morning

I have PCOS and was on clomid and glucophage. I purchased Pre-Seed 9/2/09 received it 9/4/09, started ovulating 9/7/09, and got a positive pregnancy test 9/21/09. We’ve been trying for over a year, I have no doubt Pre-Seed got us pregnant. ~ RO