In the August journal of Sexuality, Reproduction & Menopause (a publication of the American Society for Reproductive Medicine) Pre~Seed is mentioned for use by women with painful intercourse and vaginal dryness following breast cancer treatment. We are pleased to see our isotonic product mentioned in this medical journal. Pre~Seed or Pre’ can be used by women in all stages of life for isotonic, mild moisture & lubrication. Limiting irritation caused by lubricant products during love-making is important for all women, but especially those that are already having pain at intercourse. A recent study published by researchers at Ghent University discussed the potential for different lubricants to cause mucosal irritation, (referring to the tissue of the vagina). Most physicians are not aware of how hypertonic (or hyperosmotic) the leading brands of lubricant are formulated, which can lead to irritation. The study abstract is cited below.
Mucosal Irritation Potential of Personal Lubricants Relates to Product Osmolality as Detected by the SMI (Slug Mucosal Irritation Assay)
Sexually Transmitted Diseases, 2008 May;35(5):512-516
Els ADRIAENS, PhD; Jean Paul REMON, PharmD. Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
BACKGROUND: The slug mucosal irritation assay has recently been used as a sensitive measure of mucus membrane tolerance for vaginal microbicide products and carriers. In the current study, it was determined whether musosal irritation potency of personal lubricants is related to varying product osmolalities.
METHODS: Five commercial lubricants with an osmolality range were evaluated using the previously validated slug mucosal irritation assay. Specifically, Arion lusitanicus were treated with lubricants over 5 days to quantify mucus production and tissue damage, allowing assignment of each product into an irritation potency category (none, mild, moderate, or severe).
RESULTS: The irritation potency (assessed by the mucus production) of the lubricants showed a significant, quadratic relationship with the product osmolality (P = 0.001; R (2) = 0.99). Femglide, a hypo-osmotic lubricant (32 mOsm/kg), caused a negative mucus production. Pré, an iso-osmotic lubricant (316 mOsm/kg), caused no changes. Two moderately hyperosmotic lubricants, Replens and K-Y jelly (2143 and 2463 mOsm/kg), induced mild and moderate irritation, respectively. The highly hyperosmotic lubricant Astroglide (5848 mOsm/kg) resulted in severe irritation and tissue damage.
CONCLUSIONS: Commonly used personal lubricants show a full range of mucosal irritation potential, which is related to product osmolality.