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Archive for February, 2008

Paper on Pre-Seed by Cleveland Clinic Published This Week

 

We are very pleased to let you know that a full paper has been published this week in the official journal of the American Society of Reproductive Medicine “Fertility & Sterility”, citing that Pre~Seed alone did not cause changes in sperm function as compared to several other products including Astroglide, Femglide, Replens and KY.  This study is titled “Effect of vaginal lubricants on sperm motility and chromatin integrity: a prospective comparative study”, and was done by the Urological Institute and Department of ObGyn at Cleveland Clinic.  The complete reference is Fertility Sterility 2008;89:375-379.  This independent validation of PreSeed is a valuable milestone for us!   If some of you still have physicians who: a) are not aware of the potential for sperm harm with other products; or b) haven’t yet heard of Pre~Seed, this is a great article for them to review.

Take Care-  

 

Dr. E

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What is the Pre’ Lubricant Survey & Why We Need Your Help?

Click here to take our survey and get a free sample of Pre’ Lubricant.  http://www.prelubricant.com Also read more here to understand why we are doing this.  Feel free to pass the survey on to your internet community!

 Millions of couples use personal lubricants to enhance their intimacy every day. However, a substantial number of women, and even some men, experience irritation from these very products that are supposed to decrease burning and discomfort.

This is because most lubricants have formulas that are “hyperosmotic”, a big word for having too many” salt-like” substances (ions) in them. The effect is basically like when you swim in the ocean and your eyes sting, but of course the effect is “down there” where you apply the lubricant!

I am Dr. E, a woman Reproductive Physiologist. I have always had problems with irritation from lubricants. In the past, I thought that the burning I had was from intercourse, not realizing it was the lubricants causing this. And of course, every time I discussed it with a doctor they told me to use more lubricant.

I developed Pre’ Lubricant, an isotonic lubricant (meaning it has the same ion level as your body) to be less irritating. We have been fortunate enough to have Dr. Adriaens (another woman scientist) at Ghent University in Belgium, do a study to compare irritation potential of the three leading lubricants (Astroglide®, KY® & Replens®) versus Pre’.

She found that Pre’ alone caused NO irritation in her model. All three of the leading lubricants caused some irritation and actually caused tissue damage. This work is being published in the medical journal “Sexually Transmitted Diseases,” which is a good journal, but it is not a major publication that many American doctors read.

Dr. Adriaens tried to get her work published in the top US ObGyn journals, but she was told that irritation from lubricants just isn’t really that common or important. Well, we ladies know this isn’t true. However, medical America doesn’t know this, and there has never been a published study, that I could find, documenting the actual occurrence rate of this problem.

So…if you can take the time to fill out this survey, our goal is to get feedback from thousands of women & men across the US, to get some initial data on how common lubricant irritation is, and what brands it most commonly occurs with. Then we hope to write a grant to do an actual clinical study on the matter.

People have the right to know about product differences that might impact their love lives. And physicians need to know the prevalence of irritation from lubricants, even if it isn’t sexy enough for some big drug company to fund a study.

Please help us in this “guerilla” approach to bringing some real life science to this topic. Fill out the survey (it is short), and we will send you a free Pre’ sample in thanks!!

Many Thanks-

Dr. E

PS- Dr. Adriaens’ irritation test used slugs instead of rabbits, and this type of testing is becoming more popular in Europe. Although it is too bad to have to use slugs, it still is a better than the standard “rabbit irritation” test. So the more we can promote the study she did, the more we can teach the medical and scientific community in the US about this alternate irritation test!

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Pre~Seed User Survey Jan 2008

Subscribers to our e-news letter last month completed an opt-in self reporting survey.  Therefore, it is not a scientific study and represents information only, from those people who chose to respond.  Often in these cases people who feel that the product worked well for them are more likely to respond than are people that didn’t care for the product.  That said….

 

161 of you completed the survey for us. Thank You!

 

85% were using Pre~Seed primarily because you were trying to conceive

15% were using it as your routine intimate moisturizer because it didn’t cause irritation or infections as did other products.

 

Although 27% of you said that after using Pre~Seed, you would use it in the future whenever you needed extra moisture, not just during your fertile time.

 

Of the people responding:

30% became pregnant the first 2 months of using Pre~Seed

  9%  became pregnant after 3 or more months of using it 

  4% became pregnant but didn’t remember how long it took

43% of users had become pregnant at the time of this survey

 

22% of these pregnancies were sadly lost; however, this is a standard loss rate for early pregnancies.

 

20% of responders had a girl

17% had a boy

(not all pregnancies reported gender)

 

14% used Pre~Seed after trying to conceive for 0-2 months

31% after 3-6 months

18% after 7-12 months

32% after more than a year

 

21% had undiagnosed infertility

15% had a male factor issue (semen quality, etc…)

24% had a female problem (abnormal ovulation etc…)

23% were taking some fertility medication

  

What you liked best about Pre~Seed was that it didn’t harm sperm, and how it felt.

 

What you liked least was the pre-filled applicator (although many people, in contrast, actually liked these).

 

Great feedback!  Be sure and sign up for the enews letter to stay up to date on all our news!

 

Dr. E

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Cell Phone Use and Sperm Counts

A growing body of evidence suggests the electromagnetic waves from cell phones may be associated with abnormal sperm function.  In particular, a new study from the Cleveland Clinic (Agarwal et al., 2008) used obervational data to look at 361 men attending their infertility clinic.  These men were divided into groups by hours of cell phone use each day (reported by the men themselves) as follows: none,  < 2 hr/day, 2-4 hr/day and > 4 hr/day.

They then looked at sperm motility, count, and morphology (shapes).  What they found was that the percent normal morphology or shape of sperm was significantly LOWER for all cell phone using groups, as compared to men who had no use.  Sperm counts and percent motility (those that swim) were significantly worse for men using the cell phone 2 or more hours a day, and grew increasingly abnormal the longer then time on the phone each day.  The worsening sperm function (abnormal motility and morphology) seen with increasing cell phone use occurred for both men with “normal” sperm counts and those with low sperm counts.

This study echoes several other studies, including one byDavoudi et al., that was able to make men with normal sperm parameters, have abnormal motility by being on the phone 6 hrs/ day for 5 days.  Extreme, yes, but a significant effect in 5 days is pretty scary!  And this study didn’t use men with already abnormal sperm function.

At this time, it isn’t clear how other EMW exposures, such as computers or PDAs may impact sperm function.  However, if you are trying to conceive, and especially if you have male factor issues as a couple, choose the land line!

 Take Care-

 Dr. E   

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Some Valentine’s Spice

Dear Friends-

It’s that time of year when we all want a little more romance and fun from our intimate relationship.  As is my usual way, I want to recommend a few things you can try to surprise your DH (darling husband).  A somewhat graphic post so don’t read on if that will offend you, please!

1)  My first suggestion can be fun for all body types, but especially gals that have put on a little weight, and may be uncomfortable trying new things, might enjoy this.  Have the Pre’ ready and the Pre~Seed loaded if you are trying to conceive (TTC).  You can also use the left over Pre~Seed in the tube –shake it all out– to help with this.  If you are NOT trying to conceive you can have a glass of water by the bed as well.  Begin “messing” around ;) once DH has an erection, sit against the wall or bed headboard with pillows behind you. Then have DH kneel in front of you.  Apply LOTS of product to him and begin using your hands to stroke him.  You will want to use your thumb firmly along the outside ridge of his penis, and use a good bit of pressure, with the rest of your hand wrapped around him.  You can use a mix of long slower strokes, as well as shorter strokes where you mostly just flick your thumb over his glans (the tip).  During this DH can have access to play with your breasts, and if you are well endowed, he can press your breasts together, with both his hands, so that your hand is wrapped around his penis stroking him below your breasts, while his tip is thrusting up between your breasts.  NO matter what size you are, DH will enjoy the view of your face, your hand stroking him and your breasts.  If you are not TTC, DH can finish here.  If you are, be sure and switch things up in time!   Also, if you are NOT trying to conceive, and the Pre’ starts to dry just dip your fingers in the water glass, and add the water drops to you or him.  This will reactivate the product making it slippery again.  Don’t do that if you are TTC, b/c water is toxic to sperm.    

 

2) For a little longer romantic interlude, have DH start on his stomach, candles, music etc… plus a nice massage oil. Avoid any massage oils with propylene glycol, or glycerol.  They will get sticky!  Natural food stores have some nice ones with grape, rice, jojoba or sesame oil. I like the one Pier 1 sells too.  If you are TTC be careful not to get the oil around private parts, as some oils can disrupt sperm function.  You will need to have a soft pillow ready, and some hand wipes if you are TTC.  Either way, also have some Pre’ ready and get the Pre~Seed loaded! 

 

Give DH a nice back rub, then when you are ready, wipe the oil from you hands with the wipes. Ask DH to elevate his hips slightly by placing the pillow underneath his pelvis.  He stays face down. Then gently access his “package” and maneuver it so that it is pulled back and is lying on the bed between his legs, with his penis pointing down towards his feet.  This step will NOT work if he is already erect, but he CAN develop a nice erection in this position, with some different sensations.  Apply Pre’ or left over Pre~Seed to his shaft, and other areas you would like to slip and slide around.  You can wrap your hand around his shaft to stroke him in this position, or you can just use your fingers to trace up and down his shaft, and all around his back side!  If you aren’t TTC, you can use your tongue to access these same areas.  This is a unique position and will give him different sensations whether you choose to finish him this way, or switch up to take care of you!

 

Happy Lover’s Day!

 

Dr. E

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