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Archive for October, 2007

Pre~Seed Quality Control in Manufacturing in the USA

People often want to know about how our products are made. Both Pre~Seed and Pre’ are made in the USA at neighboring Unicep Packaging in Idaho. Unicep has the highest international quality certification of ISO 9001 2000.

Most lubricants are made by simply dumping ingredients together. In order to make our product with the correct pH for sperm, sub-batches must be slowly added and tested over the entire mixing process. This makes our formula challenging, and we have had several contract manufacturers tell us they simply can not make this for us if we hold them to the tight specifications we have! Even though these same groups mix most of the leading lubricant brands.

After mixing each lot of product we test it for the following, before we package it. This testing is a unique feature of our products!

pH: 7.1 to 7.4 matched to fertile cervical mucus for best sperm function
osmolality: 260 to 365 mOsm/kg, to be isotonic for sperm to not cause damage
viscosity: 7,500 to 12,000 cps, for the right amount of slippery
human sperm motility: Sperm motility after 30-minute exposure to 10% product is equal to 80% or more of the motility seen for sperm with no product present. This allows for accommodation of some slowing of sperm velocity due to increased viscosity with the lubricant products. This test is done by an independent laboratory (NW Andrology & Cryobank).

And finally, I try a sample of each lot of product before we sell it to make sure it is non-irritating to me (most lubricants cause me irritation, so I get to act like the guinea pig :) )

Taken together, we know that each batch of product we sell is “fertility-friendly” and Made in the USA for your personal use.

Take care-

Dr. E

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New study shows different impact of Viagra versus Cialis on Sperm Motility

A unique study was recently done evaluating the effects of either Viagra or Cialis on sperm motility in INFERTILE men ages 32- 39, after a ONE time dose on a semen sample taken 1-2 hours later (see bottom of the post). This study found that the average percent of motile or swimming sperm went up from 28% for controls (no meds) to 37% with the Viagra, and down to 21% with the Cialis.

Why is this study important?
1) They used younger infertile men. This is the exact population that occasionally needs a little “help” to deliver a good semen sample for assisted reproduction, or semen analysis, or during intercourse at home– who may be having “burn out” from the stress of Sex on Demand at ovulation.
2) They used one dose of the meds, like a couple might want to do to make sure there are no ED issues or stress at a critical time- again either for a fertility test or procedure, or on key days at home.
3) Viagra significantly increased average sperm motility and took it almost to a normal level (40% motile or higher is normal).

Discussion: Many, many couples who are having trouble conceiving end up with male performance issues due to a variety of reasons. This is far more common than you would think, and than your doc will tell you about – mostly because few couples tell their physician about this. These issues include: stress of sex on demand, having to have frequent intercourse (without time for a build up of desire), having to perform for a procedure or test. Ladies, imagine what it would be like if conceiving a child REQUIRED you to orgasm on a certain day!!! You can see why our men get stressed!

If performance issues arise (where DH can’t get the job done at a critical time), it can really make a couple sideways and puts even more stress on him the next time around. I have received many emails from couples where baby-dancing during a peak fertile day ended up in tears !

If you are experiencing this, or are worried about it for a big fertility procedure, ask your doctor for a one time dose of Viagra (some studies have shown chronic use may affect other types of sperm function).

Also, be sure and keep things slippery and fun for intercourse with Pre~Seed, or for manual semen collection with Pre’. The more he is stimulated the better semen sample he can produce. And part of proper stimulation is a well lubricated experience- it really does matter!

Dr. E

Fertil Steril. 2007 Oct;88(4):860-5. Epub 2007 Jun 4. Links
Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men.Pomara G, Morelli G, Canale D, Turchi P, Caglieresi C, Moschini C, Liguori G, Selli C, Macchia E, Martino E, Francesca F.
Urology Unit, Azienda Ospedaliera Pisana, University of Pisa, Pisa, Italy.

OBJECTIVE: To evaluate the acute effect of sildenafil and tadalafil on seminal parameters in young, infertile patients. DESIGN: Prospective, randomized, double-blind, crossover clinical investigation on semen parameters after the administration of a single dose of sildenafil (50 mg) or tadalafil (20 mg). SETTING: An academic hospital as well as a male infertility center and clinical andrology laboratories. PATIENT(S): Eighteen young, infertile men. INTERVENTION(S): Oral administration of a single dose of sildenafil (50 mg) or tadalafil (20 mg) in a blind, randomized order. The semen samples were collected 1 or 2 hours after each treatment. MAIN OUTCOME MEASURE(S): Changes in sperm parameters after sildenafil and tadalafil administration, compared with the basal conditions. RESULT(S): A significant increase in sperm progressive motility (median value, 37.0% vs. 28.5%) was observed after sildenafil administration as compared with baseline; in contrast, a significant decreased value was observed after tadalafil (median value, 21.5% vs. 28.5%). CONCLUSION(S): These preliminary results indicate that sperm motility appears to be acutely affected in young, infertile patients by a single dose of sildenafil and tadalafil, with opposite effects: stimulatory by the former and inhibitory by the latter.

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Why are Pre~Seed & Pre’ Less Irritating Than Other Lubricants?

The following two emails to INGfertility showcase how mild our patented formulas in Pre~Seed and Pre’ are.

“Hello and thank you for the previous supply of Pre and PreSeed samples that you sent to my office — these products have been very helpful to many of my vulvar pain patients, and also in women who are postmenopausal and have contraindications to estrogen products. I specialize in treating chronic pelvic and vulvar pain, and many of my patients have been able to have sexual contact for the first time without pain after using your product.” CO, Nurse Practitioner, San Diego, CA

“I am a 26 year old female experiencing vulvar burning and intercourse pain. I have tried just about all the lubricants sold in the drug stores and many natural substances and they all caused irritation. My doctor recently gave me a sample of pre-seed and I love it. Works great as a lubricant and didn’t irritate me at all.” DJF, New York City

What makes our formulas so unique is the fact that they are isotonic or have the same ion (salt) concentration as your body’s fluids. A recent study done at Ghent University showed that the ion concentration of a lubricant was almost perfectly related to how irritating it would be (you can see the study here http://preseed.com/TheScience/Full_Publications.php ). Specifically, the higher the ion concentration the more irritating the lubricant was, with Astroglide (having the highest ion concentration) causing actual tissue damage in the models used for this study.

Basically, most lubricants contain glycerin, glycerol or propylene glycol and these cause them to have high ion concentrations, which causes the irritation. This contact irritation is far more common than we have been told. In fact, in some studies KY products caused 20% of women to have symptoms of irritation after use.

If you feel burning or irritation after using typical lubricants, give Pre~Seed or Pre’ a try. We give you our 100% money back guarantee that our products won’t cause you irritation!

You deserve pain free intimacy!

Dr. E

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