Medical Professionals

Medical team of men and women

Why Pre-Seed is a Fertility-Friendly Lubricant

Pair of women holding babies

Pre-Seed has been extensively clinically tested and is fertility-friendly making it the perfect lubricant for couples trying to conceive. Pre-Seed’s isotonic formula matches a woman’s fertile fluids allowing sperm to swim freely through the formula. Your patients will benefit from using the applicators with Pre-Seed to have the product deposited right near the cervix. The Pre-Seed product then combines with the woman’s natural cervical mucus. This creates an optimal environment for sperm. Pre-Seed is the first lubricant allowed to claim that it is "safe for use when trying to conceive" based on regulatory review, biocompatibility testing and independent published studies.

Pre-Seed is the first lubricant with independent studies confirming that it does not harm human sperm (Agarwal et al., 2008; Vargas et al., 2011). According to Vargas et al, "Among the gels evaluated, only Pre-Seed did not show any sperm toxicity, making it the most appropriate lubricant choice for women who are trying to conceive." Pre-Seed is also recommended in several clinical textbooks, as well as in the ASRM Practice Guideline "Optimizing Natural Fertility" and in the US Library of Medicine/NIH Guidelines for helping women identify their fertile days.

Clinical Studies Show Other Lubricants Can Damage Sperm

Published studies over the past three decades have shown that most "everyday" lubricants and even olive oil, glycerin, saliva and water can impair sperm motility on contact in laboratory testing. In fact, sperm damage with leading lubricants has been cited as similar to that seen with contraceptive gels (Tulandi et al, 1982; Frishman et al, 1992; Miller et al, 1994; Kutteh et al, 1996; Anderson et al, 1998; Agarwal et al, 2008; Vargas et al, 2011). Couples who are trying to conceive should be advised to avoid lubricant products that damage sperm (learn more).

Pre-Seed's Effective Formula

Besides being "fertility-friendly," Pre-Seed Lubricant has been reported in independent studies to be as slippery and smooth as, if not better than, leading lubricants (Mahan et al, 2011). Pre-Seed’s isotonic formula has also been reported to be less irritating to mucous membranes than leading lubricants, which because of their hypertonic formulas, can cause severe irritation and even tissue damage. (Adriaens & Remon, 2008; Russo et al., 2010).

Extensive third-party testing has been done to confirm Pre-Seed Lubricant’s safety for use by couples who are trying to conceive. Additionally, each lot of Pre-Seed is tested prior to product release to ensure gamete biocompatibility.

Product Samples, Brochures, Coupons

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Adriaens E & Remon JP. Mucosal Irritation Potential of Personal Lubricants Relates to Product Osmolality as Detected by the Slug Mucosal Irritation Assay. Sexually Transmitted Diseases. 2008 May;35:512-516

Agarwal A, Deepinder F, Cocuzza M, Short RA, Evenson DP. Effect of vaginal lubricants on sperm motility and chromatin integrity: A Prospective Comparative Study. Fertility & Sterility. 2008 Feb;89:375-379.

Anderson L, Lewis SE, McClure N. The effects of coital lubricants on sperm motility in vitro. Hum Reprod 1998;13:3351-6.

Frishman GN, Luciano AA, Maier DB. Evaluation of Astroglide, a new vaginal lubricant: Effects of length of exposure and concentration on sperm motility. Ferility & Sterility. 1992;58:630-2.

Kutteh WH, Chao CH, Ritter JO, Byrd W. Vaginal lubricants for the infertile couple: Effect on sperm activity. Int J Fertil Menopausal Stud. 1996;41:400-4.

Mahan E, Morrow KM, Hayes JE. Quantitative perceptual differences among over-the-counter vaginal products using a standardized methodology: Implications for microbicide development. Contraception 2011;84:184-193.

Miller B, Klein TA, Opsahl MS. The effect of a surgical lubricant on in vivo sperm penetration of cervical mucus. Ferility & Sterility. 1994;61:1171-3.

Practice Committee of the ASRM. Optimizing natural fertility. Ferility & Sterility. 2008;90(Suppl 3):S1-6.

Russo J, Rohan LC, Moncla B et al., Safety and Anti-HIV Activity of Over-the-Counter Lubricant Gels. International Microbicides Conference 2010 Abstract #347

Tulandi T, Lpouffe L, McInnes R. Effect of saliva on sperm motility and activity. Fertility & Sterility 1984;38:721-3.

U.S. National Library of Medicine/NIH. Pregnancy-identifying fertile days. MedLine Plus. Updated 2010 Mar 30. Retrieved from

Vargas J, Crausaz M, Senn A, Germond M. Sperm toxicity of ‘nonspermicidal’ lubricant and ultrasound gels used in reproductive medicine. Fertility & Sterility. 2011;95:835-836.

Positive Patient Feedback

Healthcare providers consistently share with us that their patients "Love" Pre-Seed. Read our collection of users' stories and healthcare provider comments.